Upcoming Webinar:

International Society of Orthomolecular Medicine (ISOM):

Join me for a free live webinar online on Thursday, May 9th, at 8:00 PM Eastern, 5:00 PM Pacific Time:

Presenter: Karen von Merveldt-Guevara, MD (Germany)

In this webinar, attendees will gain comprehensive insights into thiamine (vitamin B1) and its critical role in human health, including the unrecognized epidemic of B1 deficiency within the general population.

From its utilization in the breakdown of carbohydrates, amino acids, and fatty acids, to its significance as a cofactor in essential metabolic pathways and liver health, thiamine has many implications for preventing disease. Understanding the impact of acidosis, dietary factors, and medication use on thiamine levels is significant for improving patient care.

Learn about the importance of B1 throughout the lifecycle – including the epigenetic impacts of deficiency during pregnancy, its contribution to brain development, and in delaying mental and physical decline in the elderly.


May 9 2024


5:00pm PST / 8:00pm EST

Registration: https://us06web.zoom.us/webinar/register/WN_Phjm9d87Q92asclint_2ew#/registration



Upcoming Conferences:

Medical Academy of Pediatric and Special Needs:


Join us at MAPS Fall 2024 in Scottsdale, AZ – September 5 – 7, 2024


MAPS Fall 2024



Past Conferences:




The crucial role of Thiamine (B1) in speech development, maternal risk factors and genetic implications – Prevention and Therapy:

The contribution of B1 deficiency as a stand alone factor and the subsequent drain on Biotin as a compounding factor to impaired speech development.

Few publications have as clearly demonstrated the impact of B1 (Thiamine) deficiency on speech development, syntax and lexical retrieval, as the article “Delayed language development due to infantile thiamine deficiency” by Aviva Fattal-Valevski et al. (2009) based on the longitudinal study of 20 children in Israel who had been exposed to a thiamine deficient soybased formula in infancy.

Thiamine deficiency is largely seen as a problem existing in underdeveloped countries, especially in the Asian hemisphere known for B1-deficiency caused by consumption of processed, B1-devoid white rice.

Little are we aware of the consequences of high caloric malnutrition and subsequent widespread B1-deficiency in the general population in our industrialized nations, though the increasing case load of non-alcoholic fatty liver disease as a result of these life style changes in an ever younger patient population is noted.

B1-deficiency and non-alcoholic fatty liver disease often tied in with latent or overt T2D and/or gestational diabetes are not only maternal risk factors for pre-eclampsia and eclampsia, yet are risk factors for the offspring to develop autism spectrum disorders and to suffer in particular from delayed speech development affecting higher cognitive functions as well as sensorineural disorders affecting swallowing, tongue movement and the motoric aspects of speech development.

Lastly, let us take a look together at genetic challenges in B1 processing and B1-dependent enzymes that compound the problem of B1-insufficiency and contribute to problems with speech development in our pediatric patients.



Karen von Merveldt -Guevara, German MD, graduated from Friedrich-Alexander-University in Erlangen/Nueremberg – Germany in 1996.

She works in private practice as Health Consultant at Harmonia Mundi, LLC in Sedona, AZ, remotely from Mākaha, HI as of October 2023 – Her scope of practice covers orthomolecular medicine with biochemical lab evaluations (blood, hair, and urine), as well as Integrated Manual Bodywork, which encompasses elements of Western and Eastern techniques. She offers consultation for environmental aspects of diseases (mercury amalgams, root canals, dental and orthopedic implant material incompatibility, metal, chemical and mycotoxin intoxications, housing related Issues: mold, chemicals, EMF-RF, building materials), dietary and nutritional counseling.

Patients with challenging neurological and other chronic inflammatory diseases over the past 15 years called her to study the deep biochemical changes in their tissues. The study of metal and mineral properties, their behavior in vivo, an extensive review of the body of orthomolecular literature, and a thorough analysis with comparison of different diagnostic approaches (blood biochemistry cross-referenced with hair mineral tissue analysis, and urine laboratory tests), led her to realize that routine lab tests deliver answers to many unresolved health issues when scrutinized from a novel perspective of mineral and vitamin imbalances.